Select all that apply to the use of barbiturates in treating insomnia:
1. Barbiturates deprive people of NREM sleep
2. Barbiturates deprive people of REM sleep
3. When the barbiturates are discontinued, the NREM sleep increases.
4. When the barbiturates are discontinued, the REM sleep increases.
5. Nightmares are often an adverse effect when discontinuing barbiturates.
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